Silent Mutations in the HIV-1 Reverse Transcriptase Selected during Antiretroviral Therapy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/603704

Funding Status
Closed

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Funded Activity Summary

This project seeks to determine the role of silent mutations in the HIV reverse transcriptase that are selected during drug therapy in HIV infected individuals on HIV fitness, reverse transcriptase function and the emergence of drug resistance. This study will increase our understanding of the mechanisms by which the virus evades the effects of antiretrovirals and will provide a rationale for deciding on the best drug combinations for use in patients infected with specific HIV strains (clades).

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $555,325.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

HIV-1-AIDS | HIV-AIDS | acquired immunodeficiency syndrome | drug resistance | enzyme activity | human immunodeficiency virus type I | virus replication

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