The contribution of gp130-Stat3 during Wnt-beta-catenin induced intestinal cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/603127

Funding Status
Closed

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Funded Activity Summary

There is growing evidence that cancer is initiated and develops not by the deregulation of a single gene or signaling pathway, but by multiple events. We will study the co-operation between two pathways - gp130-Stat and Wnt. These signaling pathways are frequently deregulated in many types of cancer, however their interaction remains poorly understood. We shall explore their mechanism of interaction during intestinal cancer in order to develop a novel therapeutic target for this disease.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $396,275.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Genetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

JAK-STAT pathway | colon cancer | colonic epithelium | cytokine signalling | molecular mechanisms | murine model | stem cells | therapy

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