Regulatory mechanisms and roles of calpains in skeletal muscle

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/602538

Funding Status
Closed

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Funded Activity Summary

The objectives are to understand the regulation and roles of calpains, which are proteases that break proteins in the building and repair of skeletal muscle. We will determine targets that calpains cleave and whether their location changes following activation, as well as the cellular factors regulating their activity. In addition, we will obtain information about the specific type of calpain dysfunction that occurs in particular patients with limb girdle muscular dystrophy 2A.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $439,813.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

calcium dependent proteases | excitation-contraction coupling | limb-girdle muscular dystrophy | muscle damage | muscle disease | muscle dystrophy | muscular dystrophy | musculoskeletal physiology

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