The role of assembly factors in mitochondrial Complex I biogenesis and their defects in disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/602530

Funding Status
Closed

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Funded Activity Summary

Complex I is the first complex of the mitochondrial respiratory chain that is involved in producing most of the cell's energy. Mitochondria diseases occur ~1-5,000 live births with defects in Complex I being the most prevalent, often leading to death. Complex I defects have also been implicated in common disease including Parkinson s disease. This study will provide important new information into how Complex I is built and what goes wrong to cause disease.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $608,600.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

energy metabolism | metabolic disorders | mitochondrial diseases: infant, child, adult | molecular basis of disease | molecular diagnosis | oxidative stress and apoptosis | pathogenic mechanisms | respiratory chain complexes

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