Trafficking of the major virulence protein to the host cell surface in malaria parasite-infected erythrocytes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/602506

Funding Status
Closed

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Funded Activity Summary

The malaria parasite infects human red blood cells and causes them to stick to blood vessels in the brain, inducing coma. This causes the deaths of ~2 million children each year. We will use cell biology techniques to manipulate malaria parasites to unravel the details of the molecular ticketing system that the parasite uses to get its adhesive proteins onto the red blood cell surface. The ability to interfere with this process would greatly decrease the impact of this major human pathogen.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $658,164.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Plasmodium falciparum | cerebral malaria | cytoadherence | drug resistance | laser scanning confocal microscopy | malaria | placental malaria | protein trafficking | transfection

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