Ceramide metabolism and ER stress in fatty-acid mediated destruction of pancreatic beta cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/596828

Funding Status
Closed

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Funded Activity Summary

The underlying cause of Type 2 diabetes is the failure of pancreatic beta cells to secrete sufficient insulin to overcome the insulin resistance that is associated with obesity. Beta cell failre is associated with both defective insulin secretion and loss of beta cell mass. This proposal focuses on the cellular mechanisms and stress pathways whereby too much fatty acid promotes beta cell death.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $549,092.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Type 2 diabetes | cell death-apoptosis | fatty acid and phospholipid metabolism | lipid metabolism | lipids | pancreatic beta cell | protein trafficking

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