The effect of human apoE isoforms and apoE receptors on the clearance of oligomeric A 42 by hepatocytes in vitro

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/595312

Funding Status
Closed

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Funded Activity Summary

Alzheimer's disease (AD) is a progressive memory disorder. Increased production of a short peptide called amyloid- (A ) aggregates to form the sticky masses in the brains of AD patients. The amount of A in the brain is a balance between production and clearance. Surprisingly, we recently demonstrated that the liver clears the majority of A . These results connect AD and cardiovascular disease (CVD), enabling current CVD therapeutics to target A clearance by the liver.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $424,801.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Lipids

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer's disease | Lipid disorders | apolipoprotein E | beta amyloid | cardiovascular risk factors | hepatocytes | lipoproteins | liver

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