Oxidative phosphorylation regulation and neuroprotection in optic neuropathies

Funding Activity

Website
http://grants.uberresearch.com/501100000925/http://purl.org/au-research/grants/nhmrc/590200/Energy-supply-and-nerve-protection-in-inherited-eye-diseases

Funding Status
Closed

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Funded Activity Summary

We have shown clear differences in the mitochodria, cellular organelles that generate energy, between optic atrophy patients who have good vision and those of patients who have poor vision. We believe that these changes represent a compensation mechanisms that preserves mitochondrial energy production and protects optic nerve cells. This study will characterize these differences further with the aim of identfying new treatments for preventing nerve loss and preserving vision.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $430,231.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Ophthalmology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Autosomal dominant optic atrophy | Blindness | Genetics | Glaucoma | Leber's hereditary optic neuropathy | Mitochondria | Neurodegeneration | Optic neuropathies | oxidative phosphorylation

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