The role of the glutamine transporter SNAT3 in ion transport, cell signaling and ammonia detoxification

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/585479

Funding Status
Closed

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Funded Activity Summary

Hepatic encephalopathy is a syndrome observed in patients with liver cirrhosis and is caused by increased amounts of ammonia in the blood. The proposed project investigates a transporter that is involved in ammonia and glutamine metabolism in liver and brain. The two organs are critical to the pathology of liver failure and ammonia toxicity resulting from reduced liver function. The transporter thus could become a drug target for a variety of liver diseases.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $393,249.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Glutamine metabolism | Hepatic encephalopathy | Hyperammonemia | Liver failure | Membrane transport | Structure-function analysis

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