Unique isoform-specific regulation of cardiac ryanodine receptors by calcium store proteins

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/585474

Funding Status
Closed

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Funded Activity Summary

The importance of proteins that regulate calcium stores of heart muscle is graphically illustrated by massive changes in cell structure and function, which lead to ventricular fibrillation and fatality when the proteins are disrupted. We recently made the remarkable discovery that the proteins have a unique action in the heart which enhances cardiac contraction. We will discover the interaction sites between the proteins and will define novel therapeutic targets for heart failure.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $421,160.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cardiac calsequestrin calcium binding proteins | Cardiac muscle function | Cardiac ryanodine receptor calcium release channels | Cardiac triadin and junctin | Regulation of calcium stores in the heart | heart disease | heart failure | polymorphic ventricular tachycardia | sudden cardiac death | ventricular fibrillation

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