Structural and functional characterisation of human neurotransmitter inhibitor producing enzymes glutamate decarboxylase

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/579722

Funding Status
Closed

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Funded Activity Summary

Glutamate decarboxylase (GAD) produces the major inhibitory neurotransmitter in the central nervous system, GABA. GAD dysfunction is associated with mental diseases including epilepsy and schizophrenia. We aim to understand the functional role of structural elements of GAD via x-ray crystallography and kinetic studies. We also aim to produce a high throughput GAD enzyme assay to screen compounds that can modulate GAD activity, which could be potential therapeutic targets for related disease.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2010

Funding Scheme: NHMRC Postgraduate Scholarships

Funding Amount: $35,085.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Enzyme kinetics | Enzyme regulation | Mutation analysis | Protein structure | X-ray crystallography

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