Structural Basis for Restraint and Activation of Pro-apoptotic Bax and Bak

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/575561

Funding Status
Closed

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Funded Activity Summary

The aim of this project is to understand how cell death is controlled. Defects in the cell death machinery occur in many cancers, making that machinery an attractive target for cancer therapeutics. My experiments will yield atomic resolution pictures of the functional machinery, illustrating for the first time how the molecular brakes are applied to prevent cells dying. Understanding these structures will aid the discovery of drugs that can activate the cell death machinery in cancer cells.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $246,478.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral and maxillofacial surgery

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Apoptosis | Bcl-2 | Cancer | Cell Death | Crystallography | drug development | leukaemia and apoptotis | protein-protein interaction

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