Functional suicide of selected dendritic cells by cytochrome c: an in vivo model lacking cross-presentation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/575543

Funding Status
Closed

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Funded Activity Summary

Certain white blood cells (dendritic cells) activate the immune system, especially its T cells. Infection of such cells elicits killer T cell responses. However not all infections infect dendritic cells. In such cases, the infectious material is eaten by dendritic cells and moved to certain areas within the cell. This process is called cross-presentation and how important it is during various diseases remains moot. We now have a model of testing this by eliminating these cross-presenting cells.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $597,476.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antigen presentation | autoimmunity | dendritic cells | islet transplantation | transplantation | type 1 diabetes

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