Structural Basis of Ligand Binding to Type 1 Insulin-like Growth Factor Receptor (IGF-1R)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/575539

Funding Status
Closed

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Funded Activity Summary

Insulin-like growth factors are involved in normal growth and development. However, they are also implicated in cancer development and progression. We are seeking to understand the way in which these growth factors bind to their receptor on the surface of the cell and stimulate the cell to survive, proliferate and migrate to new tumour sites. Such knowledge will be useful in the design of molecules that could potentially intervere with this process and thus be used as anti-cancer therapeutics.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $446,562.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

X-ray crystallography | cancer | cancer and related disorders | cancer chemotherapeutic agents | diabetes | insulin-like growth factors | protein tyrosine kinase | signal transduction

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