The Regulation of Antibody: A Systems Approach

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/575500

Funding Status
Closed

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Funded Activity Summary

Antibodies are made by B-cells and are essential for a functional immune system. B cells circulate in the body, and, when they encounter an invader, they mature into antibody-producing cells (ASC). A small proportion of the cells become “memory” cells with the potential to become ASC should the same infection occur in the future. This is the basis of vaccination. This program aims to understand how a B cell changes into an ASC. We aim eventually to be able to improve vaccines and understand diseases such as allergy, lupus, arthritis and leukaemia to develop novel therapies.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: Programs

Funding Amount: $8,111,315.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical microbiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B lymphocyte, Cell differentiation | Humoral and cellular immunity, Myeloma | Immunologic diseases, Antibody and drug treatment | Transcriptional regulation, Mathematical modelling | Vaccination immunology, Cell growth-differentiatio

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