State-dependence of drug binding to hERG K+ channels.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/573714

Funding Status
Closed

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Funded Activity Summary

In recent years, it has become apparent that a wide range of prescription drugs can cause inadvertent inhibition of a potassium channel in the heart known as hERG, resulting in an increased risk of cardiac arrhythmias and death. This has prompted the withdrawal from the market of 9 drugs and the introduction of mandatory testing of all drugs for inhibition of hERG channels. In this proposal we seek a molecular explanation for the promiscuity of drug binding to hERG channels

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $397,224.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cardiac arrhythmias | drug-induced arrhythmias | electrophysiology | hERG potassium channel | iatrogenicdisease | long QT syndrome | molecular basis of drug binding

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