Homeodomain Nkx2-5-dependent negative feedback loop important in heart development and congenital heart disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/573703

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Congenital heart disease (CHD) is the cause of most deaths in children in the first year of life. We have identified a genetic pathway important for both normal cardiac development and CHD that involves the cardiac transcription factor Nkx2-5. This pathway controls a transition in embryos between cardiac cell specification and expansion. We will now explore the biochemical and genetic mechanisms underlying this pathway to help us understand CHD and identify its causative genes.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $1,330,245.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Atrial Septal Defect | Congenital Heart Disease | Developmental Biology | Embryonic Progenitor Cells | Gene Regulatory Networks | Outflow Tract Malformations | Stem Cell Therapies | Tissue Engineering | Transcription Factors

Related Links