Characterising the role of streptokinase polymorphism in invasive pathogenesis of Streptococcus pyogenes.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/573406

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Invasive bacterial pathogens such as Streptococcus pyogenes, can hijack host proteins and use them to facilitate the disease process. S. pyogenes secrete streptokinase to activate a host protease (plasminogen) which is used by the bacterium to invade through host tissue. This project will characterise the molecular mechanisms involved in streptokinase mediated activation of plasminogen which will assist the generation of novel therapeutics to treat invasive diseases.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $480,535.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Allergy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Plasminogen | Streptococcus pyogenes pathogenesis | Streptokinase | Thrombolysis | bacteraemia | bacterial pathogenicity | bacterial virulence factors | necrotizing fasciitis | thrombolysis treatment

Related Links