Role of bacteriophage-encoded streptodornase in invasive disease caused by diverse group A streptococcal M serotypes.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/573401

Funding Status
Closed

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Funded Activity Summary

Streptococcus pyogenes (group A streptococcus, GAS) is estimated to cause ~700 million cases of self-limited throat or skin infection each year worldwide. Invasive GAS disease occurs in approximately 1-1000 cases, with associated mortality of 25%. We have recently discovered that a viral infection can reprogram GAS for invasive disease propensity. We will investigate whether this phenomenon is widespread, in order to understand this process and develop future therapeutics.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $832,544.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Allergy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bacterial genetics | bacterial pathogen | necrotising fasciitis | plasminogen | streptococcal disease | streptococcal infection | streptococcal invasive diseases | streptococcus | streptodornase | toxic shock syndrome

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