The interaction of Ac45 with V-ATPase and its function in osteoclastic bone resorption

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/572670

Funding Status
Closed

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Funded Activity Summary

Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and increased susceptibility to fractures. Of concern is osteoporotic fractures in the elderly are linked with increased mortality rates. Also, diseases associated with excess bone resorption place significant financial burden on the health care systems. We will examine the role of proton pump in bone resorption as a potential target for the treatment of osteoporosis.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $671,613.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Ac45 | Acidification | Aseptic loosening | Osteoarthritis | Osteoclast | Osteoporosis | bone resorption | total hip replacement

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