Mechanisms of virally-induced immunosuppression: effects on DC-NK networks

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/572641

Funding Status
Closed

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Funded Activity Summary

Cytomegalovirus (CMV) infection induces immunosuppression that often results in adverse clinical outcomes. Our previous work established that dendritic cells (DC), cells involved in the initiation of immune responses, are a principle target for CMV. This proposal will test the hypothesis that CMV-induced immunosuppression is mediated by viral interference with DC. Understanding the mechanisms involved in the induction of immunosuppression is a crucial step towards developing better therapies.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $566,308.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Dendritic cells | Immunity to infection | Immunocompromised | Immunoregulation | Immunosuppression | Immunotherapy | Natural killer cells | Viral immunity | Viral infection

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