Macrophage uncoupling protein-2 regulation and expression in inflammatory joint disease and hyperoxic lung damage

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/572638

Funding Status
Closed

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Funded Activity Summary

Oxygen radicals (OR) are made by white blood cells (WBC) when they protect against microbes and cancer cells. However, excessive production also damages normal tissue, for example in lungs that receive too much oxygen (hyperoxic lung damage) or in inflamed joints. One type of WBC, the macrophage has a protein named UCP2, that limit the amount of OR formation. This project aims to find out how macrophages activate UCP2 and whether they do so in inflammatory arthritis and hyperoxic lung damage.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $270,013.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Hyperoxic lung damage | Oxidative stress | anti-inflammatory drug therapy | hyperoxic lung damage | inflammation | inflammatory arthritis | inflammatory bowel disease | macrophage | reactive oxygen species | uncoupling protein 2

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