Mechanisms of Epithelial Damage by the Noxious Smoke Constituent Acrolein

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/572580

Funding Status
Closed

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Funded Activity Summary

Due to increasing use of reactive chemicals by terrorists (e.g. chlorine gas), their effects on the lung are receiving increasing attention in the global toxicology community. This project focusses on acrolein, the major cytotoxic substance present in smoke produced on combustion of organic matter. We will explore the mechanisms whereby acrolein and high doses of smoke cause the lung to lose its watertight properties, and also test ways of preventing such damage with drugs.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $668,813.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - lipids

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acrolein toxicity | epithelial cells | occupational lung injury | protein damage | pulmonary odema | respiratory disease | smoke inhalation injury

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