Effects of natural sequence variation on evasion of cytotoxic T lymphocytes by murine cytomegalovirus.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/572574

Funding Status
Closed

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Funded Activity Summary

Human cytomegalovirus persists for the life time of an infected person. It has many ways of achieving this, including interfering with the host immune response. This project seeks to explore this using a mouse model and murine CMV. Specifically we will focus on a set of viral genes that inhibit host recognition of virally infected cells. Sequence variation in these genes suggests that they function differently in different strains of virus: we will examine the consequences of this variation.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $553,167.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cytomegalovirus | Cytomegalovirus infection | Immune evasion | Infectious Diseases | Persistent Infection | Viral immunology

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