Regulation of gene expression in mitochondrial disease

Funded Activity Summary

Mitochondrial diseases affect 4000 children every year and most of these children do not reach adulthood. These diseases result from defects in mitochondria, energy producing compartments within cells. We have discovered a protein that controls mitochondrial gene expression and used it to rescue dysfunction in cells from patients with mitochondrial disease. We will determine its function and role in cell health, allowing us to evaluate its importance in mitochondrial disease.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $338,362.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

mitochondria | mitochondrial disease | mitochondrial function | neurodegenerative disease | optical neuropathy | oxidative phosphorylation | respiratory chain

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