Plasmodium falciparum neutral aminopeptidases: structure-function analysis for the discovery of anti-malarial drugs.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/571917

Funding Status
Closed

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Funded Activity Summary

Malaria is the world's most prevalent parasitic disease. Due to the spread of drug resistant parasites there is an urgent need to identify new anti-malaria targets and develop new drugs. We have shown that two enzymes, termed neutral aminopeptidases, are essential to the parasite's survival in the host. In this proposal we will obtain the structure of these enzymes and bring forth novel lead compounds that will form the basis of a new class of anti-malaria treatment.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $634,027.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Humoural immunology and immunochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Anaemia | Biochemistry | Blood | Drug design | Inhibitors | Malaria | Malaria control | Protein structure | Rational drug design | Tropical Disease

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