DNA vaccination using chemokine and costimulatory pathways as a treatment for chronic kidney disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/571343

Funding Status
Closed

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Funded Activity Summary

Chronic kidney disease (CKD) is a great burden on Australia. Treatments are mostly ineffective. Our DNA vaccination against mediators of inflammation can protect against CKD. On the basis of ongoing studies we have identified 5 candidate molecules involved in recruitment and activation of inflammatory cells. We outline studies to generate DNA vaccines to these molecules, enhance their efficacy, and test them in models that represent the 3 most important causes of human CKD.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $450,390.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nephrology And Urology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA vaccination | chronic renal disease | chronic renal failure | interstitial inflammatory cells | proximal kidney tubules | renal interstitial scarring | tubulointerstitial inflammation

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