Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570995

Funding Status
Closed

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Funded Activity Summary

Inherited gene mutations that cause colon cancer kill 4,700 Australians every year. About 1 in 21 Australians develop colorectal cancer by age 75. Activation of the beta-catenin protein is a critical switch in the path to colon cancer. We discovered that beta-catenin, and another protein it interacts with called IQGAP1, move between different cellular compartments. We plan to study this process in more detail, as it relates to how beta-catenin works and to understanding its role in cancer.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $511,703.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biochemistry and molecular biology | cancer chemotherapeutic agents | cell biology | cell migration | colon cancer mechanisms | colorectal cancer | inherited cancer | nuclear transport | oncogene

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