Effects of Ageing on Hepatic Drug Clearance and Mechanisms of Drug Induced Liver Disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570968

Funding Status
Closed

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Funded Activity Summary

With increasing age, there is increase in disease, for which medications may provide benefit, and an increase in the risk of adverse drug reactions, even after considering the increase in medication use by older people. We will investigate how the liver clears drugs from the blood in old age. This will guide dosing of medications for older people. We will also study how drugs injure the liver in old age and test interventions to prevent this toxicity.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $581,892.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Geriatrics And Gerontology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ageing | clinical pharmacology | dose individualisation | drug toxicity | liver | liver toxicity | pharmacology

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