The role of mutant TDP-43 in ALS

Funded Activity Summary

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of motor neurons that leads to death within 5 years of first symptoms. The only proven causes of ALS are gene mutations. But known ALS genes only account for 2% of cases. We aim to investigate a newly identified gene that encodes a protein (TDP-43) that misfolds in the motor neurons of ALS cases. We have found TDP-43 mutations in ALS patients. This exciting finding offers a unique opportunity to understand how TDP-43 causes ALS

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $472,977.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Amyotrophic lateral sclerosis | Cell biology | Genetic disease | Molecular basis of disease | Motor neuron disease | Neurodegeneration | Neurodegenerative disease

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