Cytochrome P450-mediated epoxides of polyunsaturated fatty acids that regulate cell death and survival

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570933

Funding Status
Closed

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Funded Activity Summary

Omega-3 polyunsaturated fatty acids (PUFAs) decrease cancer risk in man whereas omega-6 PUFA, which are common in western diets, increase risk. In cells cytochrome P450 converts PUFAs to epoxides. Omega-6 epoxides stimulate growth of cells and tumours but we have found that epoxides of the omega-3 eicosapentaenoic acid inhibit cell growth. We will now evaluate the mechanisms of these effects, which could lead to new anticancer treatments, perhaps based on altered diet.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $495,710.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arachidonic acid epoxidation | cancer | cardiovascular disease | cytochrome P450 | gene regulation | hypoxia-reoxygenation | nutrition | nutritional pharmacology | omega-3 fatty acids

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