PATHOGENESIS OF ALZHEIMERS DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570920

Funding Status
Closed

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Funded Activity Summary

A protein called tau has an essential role in the pathogenesis of Alzheimer's disease (AD), frontotemporal dementia (FTD) and related dementias. We have developed novel transgenic models, which allow us to treat the mice and to abrogate the clinical symptoms. As we have dissected the underlying molecular mechanisms, our ultimate goal is to develop a treatment approach based on these mechanisms and thereby reduce the socio-economic burden of these debilitating diseases.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $295,983.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Alzheimer's disease | Frontal lobe dementia (frontotemporal dementia) | anterograde axonal transport | cytoskeleton | memory impairment | parkinsonism in frontotemporal dementia | parkinsonism, amyotrophy and memory impairment | phosphorylation | therapy | transgenic mice

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