Progesterone signalling in normal and malignant breast relies on chromosomal positioning of progesterone receptor

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570865

Funding Status
Closed

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Funded Activity Summary

The cell nucleus carries genetic information that directs cell function. The nucleus is organised into compartments, which are altered in breast cancer, leading to altered function. The ovarian hormone progesterone acts via a receptor, which clumps into foci in the nucleus when active. In cancers, this clumping is disrupted. In this project we will work out how these foci control cell function, and how this leads to the specific functions of progesterone in normal breast and breast cancers.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $569,346.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

breast cancer | breast neoplasms | gene expression | progesterone | steroid hormone action | steroid hormone receptors | women's health

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