Regulation of vascular tone by kynurenine

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570861

Funding Status
Closed

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Funded Activity Summary

We have found that during infection a protein (called IDO) is made in cells lining arteries. IDO degrades tryptophan into kynurenine, which can open arteries, while blocking IDO increases blood pressure. We will now study the importance of this metabolic pathway in various diseases using mice with either absent or high levels of IDO, and also perform the first such studies in human blood vessels. We predict the research to have a tremendous impact on our understanding of cardiovascular diseases.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $665,320.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Atherosclerosis | Blood pressure | Cardiovascular diseases | Endothelium-dependent relaxation | Indoleamine 2,3-dioxygenase | Inflammation | Intra-uterine growth retardation | Nitric oxide | Stroke

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