Affinity-based profiling of bacterial Fe(III)-siderophore receptors: design strategies for antibiotics and iron overload

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570844

Funding Status
Closed

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Funded Activity Summary

In order to establish an infection, bacteria compete with the host for iron, which is in scarce supply. To access iron, bacteria produce compounds called siderophores which bind iron strongly. The iron-siderophore complex, which is unique to each bacterium, is recognised by specific receptors at the bacterial cell-surface and imported for use. In this project, we are using modified siderophores as platforms for bacteria-specific drug design with the aim of producing new antibiotics.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $275,016.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral and maxillofacial surgery

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Affinity-based protein profiling | Antibiotic development | Compounds to treat iron-overload disease | Controlling the formation of biofilms | Development of antibiotics | Fe(III)-siderophore cell-surface receptor proteins | Iron-overload disease and beta-thalassemia | Siderophores and Fe(III) acquisition in bacteria

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