Cytokine and macrophage determinants of pulmonary inflammation during tuberculosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570771

Funding Status
Closed

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Funded Activity Summary

Tuberculosis (TB) infects 33% of the world, causing over 2 million deaths per year. TB disease causes damaging lung pathology and new therapies to treat the infection and moderate inflammation are urgently required. TNF is essential for immunity to TB, acting to modulate inflammation. This grant will determine how soluble and membrane- bound TNF regulate the cellular and cytokine control of TB pathology and may lead to new therapies to limit inflammation in TB and other inflammatory diseases.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $455,899.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pathology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Mycobacterium tuberculosis | alveolar capillary membranes | cell migration | granuloma | inflammation | pulmonary oedema | pulmonary tuberculosis | reactivation | soluble and transmembrane TNF

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