Characterisation of Novel CDKL5 Targets: Implications for Rett Syndrome and Related Neurodevelopmental Disorders.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570752

Funding Status
Closed

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Funded Activity Summary

Rett syndrome (RTT) is the second most common cause of severe mental retardation in girls and women. Although two genes (MECP2 and CDKL5) responsible for RTT have been identified, we still do not understand how these genes affect brain function. The focus of this research project is to identify which proteins are controlled by CDKL5, with the express hope that a better understanding of these processes will allow us to design specfic therapies for this untreatable devasting disorder.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $421,977.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

X-linked disorder | brain development | children's disease | disease mechanisms | intellectual disability | molecular neuroscience | neurodevelopmental disorders | neuronal metabolism | protein kinases

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