Defining the dynamics and function of dendritic cells after cutaneous HSV infection in vivo.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570742

Funding Status
Closed

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Funded Activity Summary

Herpes simplex viral causes infections of the skin, eye, brain, genitals and of the newborn. HSV enters via breaks in the skin where it encounters dendritic cells, which are important for local control of the virus locally and for T cell responses. We will use two photon microscopy to visualise fluorescent HSV in mice in which DC appear green under the microscope. This will help us understand the interaction between HSV and DC in vivo which will aid design of topical antivirals and vaccines.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $419,223.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Animal models of infection and immunity | Antigen Presenting Cells | Herpes simplex virus | Herpesvirus infections | Microbiology- virology | Neonatal herpes simplex virus disease | Sexually transmitted disease | Skin | Skin response to infection | Virus Pathogenesis

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