Evolutionary events shaping the genome of Cryptococcus neoformans and their effects on pathogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/569673

Funding Status
Closed

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Funded Activity Summary

Recurring infection in patients with fungal meningitis caused by Cryptococcus neoformans is typically caused by persistence of the original infection rather than reinfection with a new strain. Our analysis of relapse strains shows that small-scale alterations frequently occur at the chromosome ends - regions containing important pathogenesis-related genes in other pathogens. We seek to characterise this microevolution further to understand how it contributes to the success of this pathogen.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: Career Development Fellowships

Funding Amount: $387,489.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

HIV-AIDS | evolution | fungal pathogens | infectious diseases | pathogenesis

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