A novel marker of distressed neurons in the hypoxic brain: Regulation, function and potential clinical utility.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/569666

Funding Status
Closed

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Funded Activity Summary

The brain is easily damaged by lack of oxygen (hypoxia). We have recently identified a novel protein called GLAST1b which is expressed in distressed neurons. This protein is a glutamate transporter. Glutamate is implicated as a toxic agent hypoxia. This study will investigate what regulates the expression of GLAST1b, what the consequences of expression are, and whether this marker can be developed as a diagnostic tool for identifying the presence of, and distribution of brain damage.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $526,878.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

NMDA | amino acid transport | brain ischaemia and traumatic injury | hypoxia-ischaemia-reperfusion injury to the brain | hypoxic-ischaemic encephalopathy | neonatal | neonatal brain injury | neonatal seizures | neuronal injury | stroke-cerebral ischaemia

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