An oral loading test to predict susceptibility to fluoropyrimidine drug toxicity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/569611

Funding Status
Closed

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Funded Activity Summary

Side-effects from anticancer drugs can be unpleasant, but may be deadly if a patient's genes are wrong for the drugs. A common chemotherapy drug, fluorouracil, can be very dangerous, but there's no simple way to predict this. We developed a simple test in which a small amount of a natural chemical is swallowed before chemotherapy. The results should allow the doctor to predict if a patient will suffer serious side effects on fluorouracil, so the dose can be reduced, or another drug tried.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $225,525.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - inorganic elements and compounds

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

breast cancer | cancer chemotherapy | colorectal cancer | drug metabolism | drug toxicity | genetic polymorphisms | gynaecological cancers | pharmacokinetics | screening | side-effects

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