Recycling endosomes governing cell polarity and cytokine secretion.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/569543

Funding Status
Closed

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Funded Activity Summary

Cytokines are chemical messengers released by cells to mount inflammatory responses to fight infections. The timing and direction of cytokine release must be tightly regulated. We investigate the cellular compartments and molecules that control cytokine secretion using sophisticated live cell imaging. Uncontrolled cytokine release is the main cause of ongoing inflammation in arthritis and inflammatory bowel disease and our studies aim to identify cellular targets for new drug development.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $958,412.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arthritis, rheumatoid | cytokine secretion | endosomes | epithelial cells | inflammation | inflammatory bowel disease | macrophage | protein trafficking

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