A -induced cell death signalling by the p75 neurotrophin receptor.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/569507

Funding Status
Closed

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Funded Activity Summary

The amyloid peptide A is central to the cause of Alzheimer's disease. We have recently found that A can activate the cell death receptor p75NTR which is found in the nerve cells that die in Alzheimer's disease. This project will study whether this death pathway underpins the neuronal death associated with Alzheimer's disease. It will also determine the mechanism by which A activates p75NTR death signalling, and identify biochemical ways to prevent this from occurring.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $546,382.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer's disease and normal aging | Cholinergic neurons | mechanisms of neuronal degeneration and the role of p75NTR | molecular mechanisms | molecular neuroscience | neurodegeneration | neuronal cell death | neurotrophic factor

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