Mechanisms of escape from progesterone-induced suppression: Role in normal and preterm birth

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/569282

Funding Status
Closed

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Funded Activity Summary

Prematurity caused by preterm birth is the leading cause of death and disease among newborns in Australia. Here we will define how the length of pregnancy is determined by the opposing actions of progesterone, which maintains pregnancy, and prostaglandins, which induce labour. We will demonstrate the mechanism by which the actions of the two hormones are balanced in normal pregnancy and disrupted in preterm labour. We will show that preterm birth can be prevented by correcting the disorder.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $547,970.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Animal Model | Parturition | Perinatal mortality and morbidity | Pregnancy complications and newborn health | Premature Birth | Preterm birth | Prevention of Prematurity | Progesterone | Prostaglandins

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