Role of the Anaphase-Promoting Complex activator Cdh1 in Oocyte Maturation and Meiotic Aneuploidy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/569202

Funding Status
Closed

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Funded Activity Summary

Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $526,878.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Aneuploidy | Embryonic development | Female Infertility | Fertility-infertility | Mammalian Eggs | Meiosis | Oocyte Maturation | Reproductive Disorders

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