Molecular Mechanisms Leading to Schizophrenia- The Role of Estrogen and Estrogen Receptor Alpha

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/568884

Funding Status
Closed

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Funded Activity Summary

Schizophrenia (SZ) is a devastating mental illness of unknown cause thought to arise from a derailment of normal brain development where the brain fails to respond to the pubertal surge in sex steroids. This proposal aims to determine the molecular pathogenesis of SZ. The SZ susceptibility gene estrogen receptor alpha and the SZ susceptibility pathway neuregulin-ErbB4 are interrogated. This will lead to the development of novel therapeutics and preventative agents that will halt disease onset.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: Early Career Fellowships

Funding Amount: $292,639.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ErbB receptors | estrogen action | gene expression | schizophrenia | transcriptional regulation

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