The Use of Nitric Oxide to Control Infections by Biofilm Forming Bacteria

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/568841

Funding Status
Closed

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Funded Activity Summary

80% of infections are the result of bacteria growing as a biofilm. It can require up to 1000x's the normal antibiotic concentration to kill a biofilm. When the bacteria disperse from the biofilm, they become antibiotic sensitive again. Our team has identified a strategy that controls biofilm dispersal. This project will design and test novel compounds that disperse biofilms so that they can be killed by the host immune response or by antibiotic treatment.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $551,767.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biotechnology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Anti-biotic resistant infection | Biofilm related infections | Development of novel therapeutic agents | Nitric oxide | Pseudomonas aeruginosa | bacterial pathogen | biofilm | chronic infection | cystic fibrosis

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