The role and inheritance of constitutional epimutations in early-onset colorectal cancer.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/568811

Funding Status
Closed

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Funded Activity Summary

Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $347,551.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Colorectal cancer | Early-onset sporadic cancers | Epigenetic screening | Epigenetics | Epigentic reprogramming | Genetic counselling | Genetics | Hereditary cancer | Hereditary non-polyposis colorectal cancer

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