Regulation of monocyte and macrophage functions by leucocyte immunoglobulin-like receptors (LILRs) in human colon

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/568771

Funding Status
Closed

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Funded Activity Summary

The human colon contains many bacteria that can invade through a damaged mucosal barrier and provoke immune cells to cause inflammation with their subsequent removal and a rapid shutdown of inflammation. Failure to clear bacteria or inflammation can lead to inflammatory bowel disease or sepsis. We will investigate how new proteins known as Leucocyte Immunoglobulin-like Receptors allow immune cells to effectively clear microorganisms without provoking uncontrolled inflammation

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $295,983.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Autoimmune diseases | Bactrial infection and sepsis | Immune dysregulation | Immune regulatory receptors | Immune tolerance of colon | Inflammation | Inflammatory bowel diseases | Lipopolysaccharide | Monocyte-macrophage activation

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