CLIC1 in immune and inflammatory responses

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/568764

Funding Status
Closed

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Funded Activity Summary

Ion channels are complex proteins that regulate salt transport in cells. We have previously cloned, and have been studying, an unusual ion channel called CLIC1, whose function is uncertain. Recent data suggests it is located in areas of white cells that are involved in regulating inflammation and mice lacking CLIC1 are protected from some immune disorders. We wish to determine the role and mechanisms whereby CLIC1 regulates immune and inflammatory responses.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $566,308.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chloride ion channel | chronic inflammatory disease | immune response | immunologic diseases | infectious diseases | inflammation | ischaemia reperfusion injury | macrophage activation | multiple sclerosis | phagosome

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